Description

Anadrol (Oxymetholone)

Anadrol (oxymetholone) is a highly potent synthetic anabolic-androgenic steroid derived from testosterone. It helps in treating conditions like anemia and osteoporosis

Anadrol (oxymetholone) is a potent, orally active synthetic anabolic-androgenic steroid (AAS) derived from dihydrotestosterone (DHT), primarily prescribed under the generic name oxymetholone. Developed in the 1960s, it is classified as a Schedule III controlled substance due to its high potency and potential for abuse.

Below is a detailed overview of its pharmaceutical profile, indications, mechanism of action, and critical clinical safety information.

Product Overview & Chemical Profile

Oxymetholone is a 17α-alkylated steroid modified to survive first-pass hepatic metabolism, allowing for effective oral administration. It possesses an exceptionally high anabolic-to-androgenic ratio, making it one of the most powerful tissue-building agents available in clinical medicine.

• Generic Name: Oxymetholone

• Common Brand Name: Anadrol®-50, Anapolon

• Dosage Form: 50 mg oral tablets

• Chemical Name: 17β-hydroxy-2-(hydroxymethylene)-17-methyl-5α-androstan-3-one

• Inactive Ingredients: Lactose, magnesium stearate, povidone, and starch

Clinical Indications

Anadrol is primarily indicated for patients suffering from severe deficiencies in red blood cell production. Its core medical applications include:

1. Deficient Red Cell Production Anemias: Treatment of acquired aplastic anemia, congenital aplastic anemia, myelofibrosis, and hypoplastic anemias.

2. Catabolic Muscle-Wasting Disorders: Off-label or international use to combat severe cachexia (muscle wasting) in patients with HIV/AIDS or severe malnutrition.

3. Osteoporosis Support: Historically utilized in specific therapeutic protocols to promote bone mineral density.

Mechanism of Action

Oxymetholone functions through two primary biological pathways:

• Erythropoiesis Stimulation: It enhances the production and secretion of erythropoietin (EPO)—the renal hormone responsible for signaling the bone marrow to manufacture red blood cells. This significantly increases the oxygen-carrying capacity of the blood.

• Androgen Receptor Activation: By binding directly to cellular androgen receptors, it alters gene transcription to accelerate protein synthesis and promote nitrogen retention within musculoskeletal tissues, driving rapid weight gain and lean mass accumulation.

Clinical Indications & Medical Uses

Anadrol is FDA-approved for the treatment of anemias caused by deficient red blood cell production. It works by increasing the production of erythropoietin, a hormone that stimulates the bone marrow to produce red blood cells.

• Approved Uses: Acquired aplastic anemia, congenital aplastic anemia, myelofibrosis, and hypoplastic anemias.

• Off-Label / Compendial Uses: Treatment of HIV/AIDS-associated wasting syndrome (cachexia) and severe muscle-wasting disorders due to its ability to drastically increase protein synthesis and weight gain.

Attribute	Specification
Active Compound	Oxymetholone (17α-alkylated steroid)
Concentration	50mg per tablet
Format	Oral tablets
Primary Medical Use	Treatment of specific anemias and muscle wasting

 

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